C₂₃H₂₂N₂O₃

Base Information

Chemical Name:C₂₃H₂₂N₂O₃
CAS No.:247171-22-8
Molecular Formula:C₂₃H₂₂N₂O₃
Molecular Weight:374.439
Hs Code.:

C<sub>23</sub>H<sub>22</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₃H₂₂N₂O₃

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Chemical Property of C₂₃H₂₂N₂O₃

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Technology Process of C₂₃H₂₂N₂O₃

There total 11 articles about C₂₃H₂₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 247171-21-7
C₂₄H₂₄N₂O₃

: 247171-22-8
C₂₃H₂₂N₂O₃

Guidance literature:: C₂₄H₂₄N₂O₃; With dibenzoyl peroxide; In dichloromethane; at 80 ℃; for 18h;

With ammonia; In methanol; at 20 ℃; for 20h;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 615-36-1
2-bromoaniline

: 247171-22-8
C₂₃H₂₂N₂O₃

Guidance literature:: Multi-step reaction with 9 steps

1.1: NEt₃; PPh₃ / Pd(OAc)2 / dimethylformamide / 20 h / 40 °C

2.1: NH₃ / methanol / 0.25 h / 20 °C

3.1: 66 percent / PCC / CH₂Cl₂ / 24 h / 40 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0 °C

4.2: 83 percent / tetrahydrofuran; hexane / 18 h / Heating

5.1: 78 percent / NaH / tetrahydrofuran / 4.5 h / 20 °C

6.1: 90 percent / NEt₃ / Pd(PPh₃)4 / acetonitrile / 40 h / 120 °C

7.1: dicyclohexylborane / tetrahydrofuran / 2 h / 0 °C

7.2: 79 percent / NaOH; H₂O / tetrahydrofuran / 1 h / 20 °C

8.1: Hg(O₂CCF₃)2 / tetrahydrofuran / 5 h

8.2: NaCl / H₂O / 3 h / 20 °C

8.3: (n-Bu)3SnH; AIBN / toluene / 2 h / 20 - 55 °C

9.1: (PhCO₂)2 / CH₂Cl₂ / 18 h / 80 °C

9.2: 74 percent / NH₃ / methanol / 20 h / 20 °C

With n-butyllithium; bis(cyclohexanyl)borane; ammonia; mercury(II) trifluoroacetate; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; dibenzoyl peroxide; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: aminocarbonylation / 2.1: deformylation / 3.1: Oxidation / 4.1: Dehydrobromination / 4.2: Condensation / 5.1: Methylation / 6.1: Cyclization / 7.1: hydroboration / 7.2: Hydrolysis / 8.1: Addition / 8.2: Substitution / 8.3: Reduction / 9.1: Oxidation / 9.2: demethylation;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 199103-44-1
1-benzyl-5-ethoxy-4-hydroxy-3-(buta-2,3-dienyl)-2-pyrrolidinone

: 247171-22-8
C₂₃H₂₂N₂O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: 42 percent / NaI / 18 h / 85 °C

2.1: NEt₃; PPh₃ / Pd(OAc)2 / dimethylformamide / 20 h / 40 °C

3.1: NH₃ / methanol / 0.25 h / 20 °C

4.1: 66 percent / PCC / CH₂Cl₂ / 24 h / 40 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C

5.2: 83 percent / tetrahydrofuran; hexane / 18 h / Heating

6.1: 78 percent / NaH / tetrahydrofuran / 4.5 h / 20 °C

7.1: 90 percent / NEt₃ / Pd(PPh₃)4 / acetonitrile / 40 h / 120 °C

8.1: dicyclohexylborane / tetrahydrofuran / 2 h / 0 °C

8.2: 79 percent / NaOH; H₂O / tetrahydrofuran / 1 h / 20 °C

9.1: Hg(O₂CCF₃)2 / tetrahydrofuran / 5 h

9.2: NaCl / H₂O / 3 h / 20 °C

9.3: (n-Bu)3SnH; AIBN / toluene / 2 h / 20 - 55 °C

10.1: (PhCO₂)2 / CH₂Cl₂ / 18 h / 80 °C

10.2: 74 percent / NH₃ / methanol / 20 h / 20 °C

With n-butyllithium; bis(cyclohexanyl)borane; ammonia; mercury(II) trifluoroacetate; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; sodium iodide; dibenzoyl peroxide; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Cyclization / 2.1: aminocarbonylation / 3.1: deformylation / 4.1: Oxidation / 5.1: Dehydrobromination / 5.2: Condensation / 6.1: Methylation / 7.1: Cyclization / 8.1: hydroboration / 8.2: Hydrolysis / 9.1: Addition / 9.2: Substitution / 9.3: Reduction / 10.1: Oxidation / 10.2: demethylation;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V