4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

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Chemical Name:4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile
CAS No.:1270980-79-4
Molecular Formula:C₂₆H₂₃F₂N₉O
Molecular Weight:515.525
Hs Code.:

Synonyms:4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

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Chemical Property of 4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

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Technology Process of 4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

There total 8 articles about 4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₇F₂N₉O₂Si

: 1270980-79-4
4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

Guidance literature:: C₃₂H₃₇F₂N₉O₂Si; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonium hydroxide; In methanol; water;

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1270980-79-4
4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C

1.2: 1 h

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol; dichloromethane / 1.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; HATU; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 301673-16-5
tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

: 1270980-79-4
4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-fluoromethylpiperazin-1-yl)carbonyl]-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium hydrogencarbonate / acetonitrile

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1.33 h

5.1: triethylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C

5.2: 1 h

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol; dichloromethane / 1.5 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h

With 1H-imidazole; hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;