(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

Base Information

Chemical Name:(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one
CAS No.:83287-29-0
Molecular Formula:C₁₃H₁₆O₄
Molecular Weight:236.268
Hs Code.:

Synonyms:(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

There total 4 articles about (3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83287-27-8
(3S,5R)-5-Benzyloxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

: 83287-29-0
(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

Guidance literature:: With perchloric acid; hydrogen; palladium on activated charcoal; In methanol; Yield given;
DOI:10.1248/cpb.30.2641

Reference yield:

: 19924-43-7
3-methoxyphenylacetonitrile

: 83287-29-0
(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropylamide / tetrahydrofuran / 1.) -78 deg C; 2.) to room temperature

2: potassium hydroxide / ethanol / 7 h / Heating

3: 80 percent / LDA / tetrahydrofuran / 1.) -78 deg C; 2.) to room temperature

4: hydrogen, trace of perchloric acid / 10percent palladized charcoal / methanol

With potassium hydroxide; perchloric acid; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.30.2641

Reference yield:

: 83287-36-9,83287-37-0
(R)-5-Benzyloxy-4-hydroxy-2-(3-methoxy-phenyl)-pentanenitrile

: 83287-29-0
(3S,5R)-5-Hydroxymethyl-3-(3-methoxy-phenyl)-3-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 7 h / Heating

2: 80 percent / LDA / tetrahydrofuran / 1.) -78 deg C; 2.) to room temperature

3: hydrogen, trace of perchloric acid / 10percent palladized charcoal / methanol

With potassium hydroxide; perchloric acid; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.30.2641