Technology Process of (R)-5-Benzyloxy-4-hydroxy-2-(3-methoxy-phenyl)-pentanenitrile
There total 1 articles about (R)-5-Benzyloxy-4-hydroxy-2-(3-methoxy-phenyl)-pentanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran;
1.) -78 deg C; 2.) to room temperature;
DOI:10.1248/cpb.30.2641
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium hydroxide / ethanol / 7 h / Heating
2: 80 percent / LDA / tetrahydrofuran / 1.) -78 deg C; 2.) to room temperature
3: hydrogen, trace of perchloric acid / 10percent palladized charcoal / methanol
4: 1.) methanolic potassium hydroxide; 2.) sodium periodate; 3.) sodium borohydride
5: 82 percent / H2O / 12 h / 180 °C / in sealed tube
6: 1.) cupric nitrate trihydrate; 2.) hydrogen / 2.) platinum / 1.) acetic anhydride, 10 deg C, 30 min; 2.) methanol
7: 60 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / Ambient temperature
8: 44 percent / sodium cyanoborohydride / Ambient temperature; pH 5-6
9: 76 percent / boron tribromide / CH2Cl2 / 1.) -78 deg C; 2.) 10 deg C
With
potassium hydroxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; perchloric acid; hydrogen; boron tribromide; sodium cyanoborohydride; copper(II) nitrate; lithium diisopropyl amide;
palladium on activated charcoal; platinum;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1248/cpb.30.2641
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium hydroxide / ethanol / 7 h / Heating
2: 80 percent / LDA / tetrahydrofuran / 1.) -78 deg C; 2.) to room temperature
3: hydrogen, trace of perchloric acid / 10percent palladized charcoal / methanol
4: 1.) methanolic potassium hydroxide; 2.) sodium periodate; 3.) sodium borohydride
5: 82 percent / H2O / 12 h / 180 °C / in sealed tube
6: 1.) cupric nitrate trihydrate; 2.) hydrogen / 2.) platinum / 1.) acetic anhydride, 10 deg C, 30 min; 2.) methanol
7: 60 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / Ambient temperature
8: 44 percent / sodium cyanoborohydride / Ambient temperature; pH 5-6
With
potassium hydroxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; perchloric acid; hydrogen; sodium cyanoborohydride; copper(II) nitrate; lithium diisopropyl amide;
palladium on activated charcoal; platinum;
In
tetrahydrofuran; methanol; ethanol; water;
DOI:10.1248/cpb.30.2641
