1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

Base Information

Chemical Name:1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol
CAS No.:1346682-60-7
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

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Chemical Property of 1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

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Technology Process of 1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

There total 3 articles about 1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 1346682-57-2
2-((3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)methyl)oxirane

: 1346682-60-7
1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

Guidance literature:: 1,2-(methylenedioxy)-4-bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

2-((3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)methyl)oxirane; With boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/jo201918d

Reference yield:

1-iodo-3,4-dimethoxybenzene: 5460-32-2
1-iodo-3,4-dimethoxybenzene

: 1346682-60-7
1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h

1.2: 4 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 3 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 0.5 h / -78 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; sodium hydroxide; In tetrahydrofuran; hexane; water; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1021/jo201918d

Reference yield:

: 6258-35-1
3-(3,4-dimethoxyphenyl)prop-2-yn-1-ol

: 1346682-60-7
1-(benzo[d][1,3]dioxol-5-yl)-3-(3-(3,4-dimethoxyphenyl)prop-2-ynyloxy)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 3 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 0.5 h / -78 °C

With n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; hexane; water;
DOI:10.1021/jo201918d