4-Hydroxymethyl-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Methyl Ester

Base Information

• Chemical Name: 4-Hydroxymethyl-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Methyl Ester
• CAS No.: 1006044-27-4
• Molecular Formula: C₁₃H₂₃NO₅
• Molecular Weight: 273.329
• Mol file: 1006044-27-4.mol

Synonyms:1-tert-butyl 4-methyl 4-(hydroxymethyl)piperidine-1,4-dicarboxylate

Chemical Property of 4-Hydroxymethyl-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Methyl Ester

Chemical Property:

• Boiling Point: 361.5±27.0 °C(Predicted)
• PKA: 14.94±0.10(Predicted)
• Density: 1.142±0.06 g/cm3(Predicted)

Purity/Quality:

≥98% ^*data from raw suppliers

1-tert-Butyl4-Methyl4-(Hydroxymethyl)piperidine-1,4-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxymethyl-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Methyl Ester

There total 6 articles about 4-Hydroxymethyl-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-(tert-butoxycarbonyl)-4-(methoxycarbonyl)piperidine-4-carboxylic acid (1005738-45-3) → 1-tert-butyl 4-methyl 4-(hydroxymethyl)piperidine-1,4-dicarboxylate (1006044-27-4)

Guidance literature:

1-(tert-butoxycarbonyl)-4-(methoxycarbonyl)piperidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; methyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.0166667h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 1h;

With water; sodium hydrogencarbonate; In tetrahydrofuran; methanol; Saturated solution;

Reference yield:

C15H23NO8 → 1-tert-butyl 4-methyl 4-(hydroxymethyl)piperidine-1,4-dicarboxylate (1006044-27-4)

Guidance literature:

C₁₅H₂₃NO₈; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃;

With methanol; In tetrahydrofuran; at 0 ℃; for 1.5h;

Reference yield:

1-tert-butyl 4-methyl 4-[(benzyloxy)methyl]piperidine-1,4-dicarboxylate → 1-tert-butyl 4-methyl 4-(hydroxymethyl)piperidine-1,4-dicarboxylate (1006044-27-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

upstream raw materials:

1-(tert-butoxycarbonyl)-4-(methoxycarbonyl)piperidine-4-carboxylic acid

formaldehyd

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate