1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide

Base Information

• Chemical Name: 1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide
• CAS No.: 221557-13-7
• Molecular Formula: C₂₁H₂₉N₃O₅
• Molecular Weight: 403.478
• Mol file: 221557-13-7.mol

Synonyms:1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide

Chemical Property of 1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide

There total 1 articles about 1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenyl chloroformate (1885-14-9) + 1-tert-butoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide (171504-88-4) → 1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide (221557-13-7)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; acetonitrile; at 50 ℃; for 1h;

DOI:10.1021/jo981939u

Reference yield: 100.0%

1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide (221557-13-7) → 1-tert-butoxycarbonyl-4-phenoxycarbonylpiperazine-2-(N-tert-butyl)carboxamide

Guidance literature:

With PF6; (S,S)-2,2''-bis<(R)-1-(diisobutylphosphino)ethyl>-1,1''-biferrocene; hydrogen; In 1,2-dichloro-ethane; at 50 ℃; for 24h; under 735.508 Torr;

DOI:10.1021/jo981939u

Reference yield:

1-tert-butoxycarbonyl-4-phenoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide (221557-13-7) → 2-tert-butylcarbamoyl-piperazine-1,4-dicarboxylic acid 1-tert-butyl ester 4-phenyl ester + 1-tert-butoxycarbonyl-4-phenoxycarbonylpiperazine-2-(N-tert-butyl)carboxamide

Guidance literature:

With PF6; (S,S)-2,2''-bis<(R)-1-(dimethylphosphino)ethyl>-1,1''-biferrocene; hydrogen; In 1,2-dichloro-ethane; at 50 ℃; for 24h; under 735.508 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo981939u

upstream raw materials:

phenyl chloroformate

1-tert-butoxycarbonyl-1,4,5,6-tetrahydropyrazine-2-(N-tert-butyl)carboxamide