(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Base Information

Chemical Name:(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine
CAS No.:190271-58-0
Molecular Formula:C₂₁H₂₀F₇NO
Molecular Weight:435.385
Hs Code.:

Synonyms:(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Suppliers and Price of (1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

There total 13 articles about (1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2S,3R)-2-(4-Fluoro-phenyl)-3-hydroxy-cyclopentanecarboxylic acid methyl ester

: 190271-58-0
(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Guidance literature:: Multi-step reaction with 9 steps

1: NaOH / methanol

2: HCl

3: HBF₄

4: 98 percent / NaOH / methanol / 60 °C

5: oxalyl chloride; DMF / CH₂Cl₂

6: aq. NaN₃ / acetone / -10 °C

7: toluene / 80 °C

8: DIPEA; DMAP / toluene / 100 °C

9: H₂ / Pd/C / ethanol

With hydrogenchloride; dmap; sodium hydroxide; tetrafluoroboric acid; sodium azide; oxalyl dichloride; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; toluene; 7: Curtius rearrangement;
DOI:10.1016/j.bmcl.2006.06.044

Reference yield:

: (+/-)-trans-3-oxo-2-(4-fluorophenyl)cyclopentane carboxylic acid methyl ester

: 190271-58-0
(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Guidance literature:: Multi-step reaction with 10 steps

1: 77 percent / NaBH₄ / methanol

2: NaOH / methanol

3: HCl

4: HBF₄

5: 98 percent / NaOH / methanol / 60 °C

6: oxalyl chloride; DMF / CH₂Cl₂

7: aq. NaN₃ / acetone / -10 °C

8: toluene / 80 °C

9: DIPEA; DMAP / toluene / 100 °C

10: H₂ / Pd/C / ethanol

With hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; sodium azide; oxalyl dichloride; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; toluene; 8: Curtius rearrangement;
DOI:10.1016/j.bmcl.2006.06.044

Reference yield:

: 190269-78-4
(1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylic acid

: 190271-58-0
(1R,2S,3S)-3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-(4-fluoro-phenyl)-cyclopentylamine

Guidance literature:: Multi-step reaction with 8 steps

1: HCl

2: HBF₄

3: 98 percent / NaOH / methanol / 60 °C

4: oxalyl chloride; DMF / CH₂Cl₂

5: aq. NaN₃ / acetone / -10 °C

6: toluene / 80 °C

7: DIPEA; DMAP / toluene / 100 °C

8: H₂ / Pd/C / ethanol

With hydrogenchloride; dmap; sodium hydroxide; tetrafluoroboric acid; sodium azide; oxalyl dichloride; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; toluene; 6: Curtius rearrangement;
DOI:10.1016/j.bmcl.2006.06.044