Technology Process of Cyclopentanecarboxylic acid, 2-(4-fluorophenyl)-3-hydroxy-,
(1R,2R,3S)-
There total 9 articles about Cyclopentanecarboxylic acid, 2-(4-fluorophenyl)-3-hydroxy-,
(1R,2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-(-)-methyl 2-(4-fluorophenyl)-3-hydroxycyclopent-1-enecarboxylate;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; toluene;
at -48 - 25 ℃;
for 3.25h;
With
sodium hydrogen sulfate; water;
In
tetrahydrofuran; toluene;
for 0.5h;
With
hydrogenchloride; methanol; sodium hydroxide; water; sodium methylate;
more than 3 stages;
- Guidance literature:
-
methyl (2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate;
With
sodium methylate;
In
methanol; toluene;
at 75 ℃;
for 1h;
With
sodium hydroxide;
In
methanol; water; toluene;
at 20 ℃;
for 3h;
Further stages.;
DOI:10.1021/jo025883m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium phosphate; johnphos / palladium diacetate / tetrahydrofuran / 12 h / 100 °C
2.1: disodium hydrogenphosphate / acetonitrile
2.2: 1.5 h / 65 °C
2.3: 0.5 h / pH < 8
3.1: 5% palladium over charcoal / ISOPROPYLAMIDE
3.2: 60 °C / 517.16 Torr
4.1: (R)-methyl oxazaborolidine; dimethylsulfide borane complex / toluene / 2.5 h / -20 °C
4.3: 20 °C
5.1: tetrahydrofuran; toluene / 0.75 h / -48 °C
5.2: 2.5 h / -25 °C
With
potassium phosphate; disodium hydrogenphosphate; (R)-methyl oxazaborolidine; dimethylsulfide borane complex; johnphos;
palladium diacetate; 5% palladium over charcoal;
In
tetrahydrofuran; ISOPROPYLAMIDE; toluene; acetonitrile;
