methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate
CAS No.:1439552-58-5
Molecular Formula:C₂₀H₁₆ClNO₃
Molecular Weight:353.805
Hs Code.:

Synonyms:methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

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Technology Process of methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

There total 7 articles about methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: methyl (E)-3-(3-(4-chlorophenyl)-5-(p-tolyl)isoxazol-4-yl)acrylate

: 1439552-58-5
methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

Guidance literature:: With rhodium(III) chloride hydrate; copper(II) acetate monohydrate; In tetrahydrofuran; Inert atmosphere; Sealed tube; Heating;
DOI:10.1021/acs.orglett.9b00446

Reference yield: 65.0%

: 14377-18-5
1-(4-methylphenyl)prop-2-yn-1-one

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1439552-58-5
methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

Guidance literature:: With silver(I) acetate; triphenylphosphine; In tetrahydrofuran; at -40 ℃; for 48h; Molecular sieve; Inert atmosphere;
DOI:10.1039/c3nj00067b

Reference yield:

: 14688-31-4
3-(4′-chlorophenyl)-5-(4′′-methylphenyl)isoxazole

: 1439552-58-5
methyl 5-(4-chlorophenyl)-4-(4-methylbenzoyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; silver(I) acetate; silver carbonate / tetrahydrofuran / Inert atmosphere; Sealed tube; Heating

2: copper(II) acetate monohydrate; rhodium(III) chloride hydrate / tetrahydrofuran / Inert atmosphere; Sealed tube; Heating

With rhodium(III) chloride hydrate; silver(I) acetate; palladium diacetate; copper(II) acetate monohydrate; silver carbonate; In tetrahydrofuran;
DOI:10.1021/acs.orglett.9b00446