14377-18-5

Basic information

• Product Name: 1-(4-methylphenyl)prop-2-yn-1-one
• Synonyms: 1-(4-methylphenyl)prop-2-yn-1-one
• CAS NO: 14377-18-5
• Molecular Weight: 144.173
• Mol File: 14377-18-5.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)prop-2-yn-1-one(14377-18-5)
• EPA Substance Registry System: 1-(4-methylphenyl)prop-2-yn-1-one(14377-18-5)

Safety Data

• Hazardous Substances Data: 14377-18-5(Hazardous Substances Data)

Usage

General Description

1-(4-methylphenyl)prop-2-yn-1-one, also known as p-methylphenylpropiophenone, is a chemical compound with the molecular formula C10H10O. It is an aryl alkynone that contains a prop-2-yn-1-one functional group and a 4-methylphenyl substituent. 1-(4-methylphenyl)prop-2-yn-1-one is commonly used in organic synthesis and pharmaceutical research as a precursor for the synthesis of various pharmaceuticals and other organic compounds. It is also known for its potential pharmacological properties, although further research is needed to fully understand its biological activities. Additionally, this chemical has applications in the field of material science, particularly in the development of novel polymeric materials and coatings.

Upstream product

• 132589-36-7 1-(4-methylphenyl)prop-2-yn-1-ol 
• 104-87-0 4-methyl-benzaldehyde 
• 910219-57-7 1-(4-methylphenyl)-3-(trimethylsilyl)-2-propyn-1-ol 
• 37166-45-3 1-(4''methylphenyl)-3-(trimethylsilyl)prop-2-ynone 

Downstream Products

• 108362-06-7 2-ethyl-5-(p-tolyl)furan 
• 1142923-50-9 C₂₂H₂₃NO₃ 
• 1142923-59-8 C₂₃H₂₅NO₃ 
• 1233884-69-9 C₂₇H₂₉NO₃S 
• 1182441-50-4 quinolin-3-yl(p-tolyl)methanone 
• 1338721-52-0 1-methyl-N-((E)-3-oxo-3-p-tolylprop-1-enyl)-N-phenyl-1H-imidazole-2-carboxamide 
• 1411840-88-4 C₂₀H₁₆O₂ 
• 1423136-98-4 methyl 4-(4-methylbenzoyl)-5-(4-nitrophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 1423136-99-5 methyl 4-(4-methylbenzoyl)-5-(4-nitrophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 118714-26-4 6-methyl-2-(p-tolyl)quinoline 

Relevant articles and documents

Calcium phosphate-vanadate apatite (CPVAP)-catalyzed aerobic oxidation of propargylic alcohols with molecular oxygen

Calcium phosphate-vanadate apatite (CPVAP) works effectively as a catalyst for the aerobic oxidation of propargylic alcohols to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Moreover, CPVAP can be readily separated by filtration and reused at least 10 times without appreciable loss of the catalytic activity.

Multisubstituted pyrazole synthesis via [3?+?2] cycloaddition/rearrangement/N[sbnd]H insertion cascade reaction of α-diazoesters and ynones

The cascade reactions of alkyl α-diazoesters and ynones using Al(OTf)3 as the catalyst are described. A series of 4-substituted pyrazoles were obtained via [3 + 2] cycloaddition, 1,5-ester shift, 1,3-H shift, and N[sbnd]H insertion process. Deuterium labelling experiments, kinetic studies and control experiments were carried out for the rationalization of the mechanism.

Enantioselective [3 + 2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis

An asymmetric [3 + 2] annulation reaction of 4-isothiocyanato pyrazolones with alkynyl ketones in the presence of an organic catalyst derived from a cinchona alkaloid under mild conditions is realized. This protocol provides unprecedented expeditious access to a wide range of optically active spiro[pyrroline-pyrazolones] with various electronic properties in high yields with good to excellent enantioselectivities.

Copper-catalyzed method for preparing aldehyde or ketone compound by oxidizing alcohol with oxygen as oxidizing agent and application

The invention discloses a copper-catalyzed method for preparing an aldehyde or ketone compound by oxidizing alcohol with oxygen as an oxidizing agent. Reaction is performed in an organic solvent for 4-48 hours at room temperature by using copper salt and nitroxide free radicals as catalysts and oxygen or air as an oxidizing agent to efficiently oxidize an alcohol compound into the corresponding aldehyde or ketone compound. The method is simple to operate, free of chlorides corrosive to equipment, available in raw materials and reagents, mild in reaction conditions, wide in substrate universality, good in functional group compatibility, convenient in separation and purification, environmentally friendly in the whole process and free of pollution, and is a method suitable for industrial production.