Piv-PTL-PTL-OBn

Base Information

• Chemical Name: Piv-PTL-PTL-OBn
• CAS No.: 219754-08-2
• Molecular Formula: C₂₈H₃₈N₂O₄
• Molecular Weight: 466.621
• Mol file: 219754-08-2.mol

Synonyms:Piv-PTL-PTL-OBn

Chemical Property of Piv-PTL-PTL-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piv-PTL-PTL-OBn

There total 10 articles about Piv-PTL-PTL-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(1R,2S,5S)-3-(2,2-Dimethyl-propionyl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (219754-06-0) + (1R,2S,5S)-6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid benzyl ester (219754-07-1) → Piv-PTL-PTL-OBn (219754-08-2)

Guidance literature:

With benzotriazol-1-ol; diisopropyl-carbodiimide;

DOI:10.1021/jo981814p

Reference yield:

(1R,2S,5S)-(6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-yl)methanol (394734-84-0) → Piv-PTL-PTL-OBn (219754-08-2)

Guidance literature:

Multi-step reaction with 7 steps

1: CH₂Cl₂

2: 70 percent / Jones' reagent

3: 76 percent / DIC, DMAP

4: TFA

5: Huenid's base

6: 99 percent / H₂ / Pd-C

7: 75 percent / diisopropylcarbodiimide, hydroxybenzotriazole

With dmap; jones' reagent; hydrogen; benzotriazol-1-ol; dacarbazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; In dichloromethane;

DOI:10.1021/jo981814p

Reference yield:

((1R,2S,5S)-3-Benzyl-6,6-dimethyl-3-aza-bicyclo[3.1.0]hex-2-yl)-methanol (1026427-11-1) → Piv-PTL-PTL-OBn (219754-08-2)

Guidance literature:

Multi-step reaction with 8 steps

1: H₂ / Pd-C / 2585.7 Torr

2: CH₂Cl₂

3: 70 percent / Jones' reagent

4: 76 percent / DIC, DMAP

5: TFA

6: Huenid's base

7: 99 percent / H₂ / Pd-C

8: 75 percent / diisopropylcarbodiimide, hydroxybenzotriazole

With dmap; jones' reagent; hydrogen; benzotriazol-1-ol; dacarbazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; In dichloromethane;

DOI:10.1021/jo981814p

upstream raw materials:

(1R,2S,5S)-3-(2,2-Dimethyl-propionyl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid

(1R,2S,5S)-6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid benzyl ester

pivaloyl chloride

(1R,2S,5S)-(6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-yl)methanol