(2S,3S)-3-benzyloxy-2-hexyldecanoic acid

Base Information

Chemical Name:(2S,3S)-3-benzyloxy-2-hexyldecanoic acid
CAS No.:932394-94-0
Molecular Formula:C₂₃H₃₈O₃
Molecular Weight:362.553
Hs Code.:

Synonyms:(2S,3S)-3-benzyloxy-2-hexyldecanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-3-benzyloxy-2-hexyldecanoic acid

Chemical Property:

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Technology Process of (2S,3S)-3-benzyloxy-2-hexyldecanoic acid

There total 6 articles about (2S,3S)-3-benzyloxy-2-hexyldecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-hexyl-3-trimethylsilanyloxy-decanoic acid tert-butyl ester

: 100-52-7
benzaldehyde

: 932394-94-0
(2S,3S)-3-benzyloxy-2-hexyldecanoic acid

Guidance literature:: With triethylsilane; trimethylsilyl trifluoromethanesulfonate; at -78 - 20 ℃; for 2.25h;
DOI:10.1021/jo062018j

Reference yield: 76.0%

: 932394-94-0
(2S,3S)-3-benzyloxy-2-hexyldecanoic acid

Guidance literature:

Reference yield:

: 66697-00-5
tert-butyl 3-oxodecanoate

: 932394-94-0
(2S,3S)-3-benzyloxy-2-hexyldecanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84 percent / hydrogen / RuCl₂[(S)-BINAP] / methanol / 72 h

2.1: LDA / tetrahydrofuran; diethyl ether / 0.5 h / -48 °C

2.2: 41 percent / HMPA / tetrahydrofuran; diethyl ether / 6 h / -48 °C

3.1: triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 76 percent / triethylsilane; trimethylsilyl triflate / 2.25 h / -78 - 20 °C

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; hydrogen; triethylamine; lithium diisopropyl amide; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Noyori reduction / 2.2: Frater alkylation;
DOI:10.1021/jo062018j