methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

Base Information

Chemical Name:methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate
CAS No.:1233249-62-1
Molecular Formula:C₂₈H₂₃ClN₂O₄
Molecular Weight:486.955
Hs Code.:

Synonyms:methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

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Chemical Property of methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

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Technology Process of methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

There total 11 articles about methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-61-0
C₂₀H₁₄ClNO₄

: 156-41-2
4-chlorophenylethylamine

: 1233249-62-1
methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

Guidance literature:: With pyridine; In chloroform; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-60-9
4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-l-yl]carbonyl}benzoic acid

: 156-41-2
4-chlorophenylethylamine

: 1233249-62-1
methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

Guidance literature:: 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-l-yl]carbonyl}benzoic acid; With oxalyl dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chlorophenylethylamine; With pyridine; In chloroform; at 20 ℃; for 14h;

Reference yield:

: C₂₂H₁₈ClNO₄

: 1233249-62-1
methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; acetonitrile

1.2: 20 °C

2.1: diazomethyl-trimethyl-silane / 20 °C

3.1: trifluoroacetic acid / chloroform / 0 - 50 °C

4.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 20 °C

5.1: pyridine / chloroform / 20 °C

With pyridine; oxalyl dichloride; trifluoroacetic acid; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile; 1.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009