2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-11-7
Molecular Formula:C₂₇H₂₁ClN₂O₄
Molecular Weight:472.928
Hs Code.:

Synonyms:2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

There total 14 articles about 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1233249-62-1
methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate

: 1233248-11-7
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

: 1233248-11-7
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / chloroform / 1 h / 50 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 14 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3.2: Cooling with ice

With oxalyl dichloride; water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: C₂₂H₁₈ClNO₄

: 1233248-11-7
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; acetonitrile

1.2: 20 °C

2.1: diazomethyl-trimethyl-silane / 20 °C

3.1: trifluoroacetic acid / chloroform / 0 - 50 °C

4.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 20 °C

5.1: pyridine / chloroform / 20 °C

6.1: water; sodium hydroxide / tetrahydrofuran / 20 °C

With pyridine; oxalyl dichloride; water; trifluoroacetic acid; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile; 1.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009