Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate

Base Information

Chemical Name:Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate
CAS No.:344349-73-1
Molecular Formula:C₁₄H₁₅NO₃
Molecular Weight:245.278
Hs Code.:
DSSTox Substance ID:DTXSID301260331
Nikkaji Number:J3.322.899F

Synonyms:DTXSID301260331;344349-73-1;Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate

Suppliers and Price of Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:245.10519334
Heavy Atom Count:18
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=C(N=C(O1)C2=CC=CC=C2)C(=O)OCC

Technology Process of Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate

There total 4 articles about Ethyl 5-ethyl-2-phenyl-4-oxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1593269-58-9
2-benzoylamino-3-oxo-pentanoic acid ethyl ester

: 344349-73-1
ethyl 5-ethyl-2-phenyl-1,3-oxazole-4-carboxylate

Guidance literature:: With trichlorophosphate; In chloroform; for 1h; Reflux;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 344349-73-1
ethyl 5-ethyl-2-phenyl-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite; acetic acid / water / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen; hydrogenchloride / ethanol / 20 °C

3: triethylammonium acetate / dichloromethane / 2 h / 20 °C

4: trichlorophosphate / chloroform / 1 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylammonium acetate; acetic acid; sodium nitrite; trichlorophosphate; In ethanol; dichloromethane; chloroform; water;
DOI:10.1248/cpb.c13-00513

Reference yield:

: ethyl 2-amino-3-oxopentanoate hydrochloride

: 344349-73-1
ethyl 5-ethyl-2-phenyl-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylammonium acetate / dichloromethane / 2 h / 20 °C

2: trichlorophosphate / chloroform / 1 h / Reflux

With triethylammonium acetate; trichlorophosphate; In dichloromethane; chloroform;
DOI:10.1248/cpb.c13-00513