tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

Base Information

Chemical Name:tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate
CAS No.:736151-97-6
Molecular Formula:C₁₇H₂₅N₃O₅
Molecular Weight:351.403
Hs Code.:

Synonyms:tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

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Chemical Property of tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

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Technology Process of tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

There total 3 articles about tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 736151-95-4
tert-butyl (4S,5S,1'S)-5-(1'-cyanohydroxymethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

: 736151-97-6
tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; at 20 ℃; for 2h;
DOI:10.1021/ol049215u

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 736151-97-6
tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (R,R)-3,4,5-F₃-C₆H₂-NAS-Br; aq. NaOH / 1,3,5-trimethyl-benzene / 6 h / -20 °C

1.2: 1.04 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2.1: DIBAL-H / CH₂Cl₂; diethyl ether; toluene / 1 h / -78 °C

2.2: 32 percent / CH₂Cl₂; diethyl ether; toluene / 7 h / -78 - 0 °C

3.1: AcOH; H₂ / PtO₂ / 2 h / 20 °C

With sodium hydroxide; (R,R)-3,4,5-F₃-C₆H₂-NAS-Br; hydrogen; diisobutylaluminium hydride; acetic acid; platinum(IV) oxide; In diethyl ether; dichloromethane; toluene; 1,3,5-trimethyl-benzene; 1.1: Mannich reaction;
DOI:10.1021/ol049215u

Reference yield:

: 736151-93-2
4-tert-butyl 5-ethyl (4S,5S)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4,5-dicarboxylate

: 736151-97-6
tert-butyl (4S,5S,1'R)-5-(2'-amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIBAL-H / CH₂Cl₂; diethyl ether; toluene / 1 h / -78 °C

1.2: 32 percent / CH₂Cl₂; diethyl ether; toluene / 7 h / -78 - 0 °C

2.1: AcOH; H₂ / PtO₂ / 2 h / 20 °C

With hydrogen; diisobutylaluminium hydride; acetic acid; platinum(IV) oxide; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol049215u