N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Base Information

Chemical Name:N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide
CAS No.:1095004-79-7
Molecular Formula:C₂₈H₃₂FN₅O₄
Molecular Weight:521.592
Hs Code.:

Synonyms:N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Suppliers and Price of N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

There total 12 articles about N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095006-08-8
3-[3-[[1-[2-(2-chloroethoxy)phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

: 141-43-5
ethanolamine

: 1095004-79-7
N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

: 201849-17-4
1-bromo-2-chloro-5-fluoro-4-methylbenzene

: 1095004-79-7
N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 12 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 27 h / 90 °C

2: sodium hydroxide; water / methanol / 1 h / 25 °C

3: sulfuric acid; potassium nitrate / 1.17 h / 0 - 50 °C

4: methanol / 22 h / 20 - 50 °C

5: ammonium formate / 5%-palladium/activated carbon / ethanol / 62 h / 75 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / Heating / reflux

7: dichloromethane; N,N-dimethyl-formamide / 16.25 h / 0 - 20 °C / Heating / reflux

8: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 8 h / 100 °C

9: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 75 °C

10: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / 20 °C

11: caesium carbonate / acetonitrile / 16 h / 80 °C

12: 1,4-dioxane / 16 h / 100 °C

With sodium hydroxide; sulfuric acid; water; isopropylmagnesium chloride; ammonium formate; caesium carbonate; potassium nitrate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 103877-62-9
2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

: 1095004-79-7
N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: methanol / 22 h / 20 - 50 °C

2: ammonium formate / 5%-palladium/activated carbon / ethanol / 62 h / 75 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / Heating / reflux

4: dichloromethane; N,N-dimethyl-formamide / 16.25 h / 0 - 20 °C / Heating / reflux

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 8 h / 100 °C

6: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 75 °C

7: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / 20 °C

8: caesium carbonate / acetonitrile / 16 h / 80 °C

9: 1,4-dioxane / 16 h / 100 °C

With isopropylmagnesium chloride; ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;