N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine

Base Information

• Chemical Name: N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine
• CAS No.: 360049-07-6
• Molecular Formula: C₁₁H₁₁F₃N₂O₃
• Molecular Weight: 276.215
• Mol file: 360049-07-6.mol

Synonyms:N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine

Chemical Property of N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine

There total 2 articles about N²-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloroformic acid ethyl ester (541-41-3) + N'-hydroxy-3-(trifluoromethyl)benzenecarboximidamide (40067-80-9) → N2-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine (360049-07-6)

Guidance literature:

With triethylamine; In chloroform; at 25 ℃;

DOI:10.1039/b009451j

Reference yield:

3-trifluoromethylbenzonitrile (368-77-4) → N2-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine (360049-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / aq. Na₂CO₃; hydroxylamine hydrochloride / ethanol / Heating

2: 99 percent / Et₃N / CHCl₃ / 25 °C

With hydroxylamine hydrochloride; sodium carbonate; triethylamine; In ethanol; chloroform;

DOI:10.1039/b009451j

Reference yield: 71.0%

N2-(Ethoxycarbonyloxy)-3-trifluoromethylbenzamidine (360049-07-6) → 3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one

Guidance literature:

In xylene; Heating;

DOI:10.1039/b009451j

upstream raw materials:

chloroformic acid ethyl ester

N'-hydroxy-3-(trifluoromethyl)benzenecarboximidamide

3-trifluoromethylbenzonitrile

Refernces