1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester

Base Information

• Chemical Name: 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester
• CAS No.: 1023695-49-9
• Molecular Formula: C₁₃H₁₇ClN₂O₄
• Molecular Weight: 300.742
• Mol file: 1023695-49-9.mol

Synonyms:1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester

Chemical Property of 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester

There total 9 articles about 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

o-chlorobenzaldehyde N-(tert-butoxycarbonyl)imine + nitromethane (75-52-5) → 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester (1023695-49-9)

Guidance literature:

With 2,6-bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine; nickel(II) acetate tetrahydrate; In 1,4-dioxane; at 20 ℃; for 20h; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0034-1378204

Reference yield: 90.0%

nitromethane (75-52-5) + o-chlorobenzaldehyde N-(tert-butoxycarbonyl)imine (848194-75-2) → 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester (1023695-49-9)

Guidance literature:

With N-((1R,2R)-2-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; In acetonitrile; at -20 ℃; Molecular sieve;

DOI:10.1021/ja803538x

Reference yield: 90.0%

o-chlorobenzaldehyde N-(tert-butoxycarbonyl)imine + nitromethane (75-52-5) → 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester (1023695-49-9) + 1-(o-chlorophenyl)-2-nitroethylcarbamic acid t-butyl ester

Guidance literature:

With Resin 24; at 20 ℃; for 2h;

DOI:10.1039/c4gc02474e

upstream raw materials:

nitromethane

o-chlorobenzaldehyde N-(tert-butoxycarbonyl)imine

N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-2-chlorobenzylamine

tert-butyl carbazate