5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide

Base Information

• Chemical Name: 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide
• CAS No.: 1394017-33-4
• Molecular Formula: C₂₀H₁₆ClF₃N₂O₂
• Molecular Weight: 408.807
• Mol file: 1394017-33-4.mol

Synonyms:5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide

Chemical Property of 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide

There total 3 articles about 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride (1394017-92-5) + 5-chloro-2-(trifluoromethyl)benzoic acid (654-98-8) → 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide (1394017-33-4)

Guidance literature:

5-chloro-2-(trifluoromethyl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.07.032

Reference yield: 81.0%

5-chloro-2-(trifluoromethyl)benzoic acid (654-98-8) + 4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride → 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide (1394017-33-4)

Guidance literature:

5-chloro-2-(trifluoromethyl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 54.0%

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride (1394017-92-5) + 5-chloro-2-trifluoromethylbenzoic acid chloride (320-84-3) → 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide (1394017-33-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.07.032

upstream raw materials:

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride

5-chloro-2-(trifluoromethyl)benzoic acid

5-chloro-2-trifluoromethylbenzoic acid chloride