5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester
• CAS No.: 172876-08-3
• Molecular Formula: C₄₃H₄₀N₆O₂
• Molecular Weight: 672.83
• Mol file: 172876-08-3.mol

Synonyms:5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Chemical Property of 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

There total 6 articles about 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Oxalic acid 5-ethoxycarbonyl-2-propyl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazol-4-ylmethyl ester ethyl ester → 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester (172876-08-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1.5h; Heating;

DOI:10.1021/jm950450f

Reference yield:

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester (172876-08-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / HCl / Ambient temperature

2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

3: 69 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C

4: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

5: 87 percent / Bu₃SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tri-n-butyl-tin hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm950450f

Reference yield:

diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate (144689-94-1) → 5-Methyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester (172876-08-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

2: 69 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 87 percent / Bu₃SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating

With 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tri-n-butyl-tin hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm950450f

upstream raw materials:

2-propyl-1H-imidazole-4,5-dicarboxylic acid

diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

5-Hydroxymethyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

2-Propyl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid diethyl ester

Downstream raw materials:

5-Methyl-2-propyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester