58954-23-7

Usage

Uses

2-Propylimidazole-4,5-dicarboxylic acid is a useful research chemical compound.

Chemical Properties

White flake crystal

InChI:InChI=1/C8H10N2O4/c1-2-3-4-9-5(7(11)12)6(10-4)8(13)14/h2-3H2,1H3,(H,9,10)(H,11,12)(H,13,14)

Synthetic route

2-propylimidazole-4,5-dicarbonitrile (51802-42-7) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With hydrogenchloride In water at 100℃; for 0.0333333h; Temperature;	96.5%
With hydrogenchloride; water for 4h; Reflux; Large scale reaction;	95%
With hydrogenchloride for 8h; Heating;	80%

2-propyl-1H-benzimidazole (5465-29-2) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With sodium tungstate; disodium hydrogenphosphate; potassium dihydrogenphosphate; dihydrogen peroxide In water at 100℃; for 1h; pH=4.9; Concentration; pH-value; Temperature;	85.5%
With sulfuric acid; dihydrogen peroxide In water at 100 - 120℃; for 0.5h; Concentration;	72%
With sulfuric acid; dihydrogen peroxide In water for 3h; Reflux;	35%

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate (144689-94-1) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 50℃; for 4h;	85%

L-Tartaric acid (87-69-4) + butyraldehyde (123-72-8) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
Stage #1: L-Tartaric acid With sulfuric acid; nitric acid at 43 - 46℃; for 1.61667h; Stage #2: butyraldehyde With ammonium hydroxide In 1-methyl-pyrrolidin-2-one at -10 - 4℃; Solvent; Temperature;	46%

2-propyl-1H-benzimidazole (5465-29-2) → 4,5-imidazoledicarboxylic acid (570-22-9) + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With sulfuric acid; dihydrogen peroxide In water at 100 - 130℃;	A 31% B 1%

butyraldehyde (123-72-8) + dinitrate of/the/ (+)-tartaric acid → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With ammonia

di-O-nitro-tartaric acid (610-20-8) + butyraldehyde (123-72-8) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
With ammonium hydroxide at 0℃; for 0.5h;	97 g

1,1,1-trimethoxybutane (43083-12-1) + diaminomaleonitrile (1187-42-4) → 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7)

Conditions	Yield
In methanol Reflux;

methanol (67-56-1) + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → 2-propyl-4,5-bis(methoxycarbonyl)-imidazole (124750-59-0)

Conditions	Yield
With thionyl chloride at 40 - 45℃; Large scale reaction;	96%
With thionyl chloride at 43℃; for 11h;
Stage #1: methanol; 2-propyl-1H-imidazole-4,5-dicarboxylic acid With thionyl chloride Reflux; Stage #2: With sodium hydroxide In water for 0.25h;

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + ethanol (64-17-5) → 2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate (144689-94-1)

Conditions	Yield
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid; ethanol With hydrogenchloride; thionyl chloride at 5℃; for 0.166667h; Stage #2: for 1.5h; Heating;	94%
With hydrogenchloride Ambient temperature;	86%
With thionyl chloride In water at 8℃; for 6.6h; Temperature; Reflux;	77%
at 0℃; for 12h; Reflux;

cobalt(II) nitrate hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) + dimethyl sulfoxide (67-68-5) → C16H22CoN4O10*2C2H6OS

Conditions	Yield
In methanol at 80℃; for 72h;	88.49%

cobalt(II) chloride hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → [Co3(pimda)2(H2O)5]

Conditions	Yield
With triethylamine In water at 170℃; for 96h; Autoclave;	84%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) + zinc(II) chloride (7646-85-7) → diaquabis(2-propyl-4,5-imidazoledicarboxylato)zinc(II) tetrahydrate

Conditions	Yield
In ethanol; water ligand dissolved in H2O at room temp., mixed with EtOH soln. of ZnCl2, heated at 70°C for 8 h; crystd. at room temp. for 5 d, washed (H2O), elem. anal.;	81.3%
In ethanol; water imidazole-compd. dissolved in H2O, Zn-compd. dissolved in EtOH, two solution mixed, heated to 70°C for 8 h; filtered, evaporated at room temp. for 5 d, washed with H2O, elem. anal.;	81.3%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + zinc(II) acetate dihydrate (5970-45-6) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → diaquabis(2-propyl-4,5-imidazoledicarboxylato)zinc(II) - N,N-dimethylformamide (1/2)

Conditions	Yield
In water; N,N-dimethyl-formamide ligand dissolved in H2O at room temp., mixed with DMF soln. of Zn(CH3COO)2*2H2O, refluxed for 8 h; crystd. at room temp. for 15 d, washed (H2O), elem. anal.;	78%
In water; N,N-dimethyl-formamide imidazole-compd. dissolved in H2O at room temp., Zn-compd. dissolved in DMF, two solution mixed, refluxed for 8 h; filtered, evaporated at room temp. for 15 d, washed with H2O, elem. anal.;	78%

cadmium(II) nitrate tetrhydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → Cd(2-propyl-1H-imidazole-4,5-dicarboxylic acid(-1H))2(H2O)2*4H2O

Conditions	Yield
With 3,3',4,4'-biphenyltetracarboxylic acid In water mixt. of acid and Cd(NO3)2*4H2O dissolved in H2O; stirred for 0.5 h; heated at 75°C for 3 d; elem. anal.;	77%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + copper(II) acetate monohydrate (6046-93-1) → [Cu(2-propylimidazole-4-carboxylato-5-carboxylic acid)2]n

Conditions	Yield
In water at 20 - 130℃; Sealed tube;	75%

cadmium(II) nitrate tetrhydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → [Cd2(2-propyl-1H-imidazole-4,5-dicarboxylic acid(-2H))2(DMF)2

Conditions	Yield
With benzidine; terephthalic acid In water; N,N-dimethyl-formamide mixt. of imidazole deriv., Cd nitrate, benzidine, terephthalic adcid heated in mixt. DMF/H2O heated at 75°C for 48 h; washed by water, dried in air; elem. anal.;	74%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + zinc diacetate (557-34-6) + water (7732-18-5) → Zn(2-propyl-1H-imidazole-4,5-dicarboxylic acid(-1H))2(H2O)2*3.5H2O

Conditions	Yield
With 3,3',4,4'-biphenyltetracarboxylic acid In water mixt. of acid and Zn(OAc)2 dissolved in H2O; stirred for 0.5 h; heated at 75°C for 3 d; elem. anal.;	72%

4,4'-bipyridine (553-26-4) + manganese (II) sulfate monohydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → [Mn3(2-propyl-4,5-imidazoledicarboxylate(2-))2(2-propyl-4,5-imidazoledicarboxylate(1-))2(4,4'-bipyridine)2(H2O)2]n

Conditions	Yield
With sodium hydroxide In ethanol; water; acetonitrile at 130℃; for 48h; pH=6.5; Sealed tube; High pressure;	71%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + cadmium(II) acetate dihydrate (5743-04-4) → [Cd(2-propyl-4,5-imidazoledicarboxylic acid(-1H))2]n

Conditions	Yield
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid With sodium hydroxide In water at 20℃; pH=6; Stage #2: cadmium(II) acetate dihydrate In ethanol; water at 75℃; for 8h;	70.8%
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid; cadmium(II) acetate dihydrate In water for 0.333333h; Stage #2: In water at 180℃; for 120h; Sealed tube;	35.2%

copper(II) choride dihydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → [Cu(2-propyl-4,5-imidazoledicarboxylic acid(-1H))2] (1233863-63-2)

Conditions	Yield
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid With sodium hydroxide In water at 20℃; pH=6.5; Stage #2: copper(II) choride dihydrate In ethanol; water at 70℃; for 8h;	70.8%

lead(II) acetate trihydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → [Pb(2-propyl-4,5-imidazoledicarboxylic acid(-1H))2(water)2]n

Conditions	Yield
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid With sodium hydroxide In water at 20℃; pH=6; Stage #2: lead(II) acetate trihydrate In ethanol; water at 75℃; for 8h;	70.8%

1,10-Phenanthroline (66-71-7) + cobalt(II) nitrate hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → [Co(2-propyl-1H-imidazole-4,5-dicarboxylic acid(-3H))(1,10-phenanthroline)]*H2O (1389320-06-2)

Conditions	Yield
In water High Pressure; Co compd., ligand, and phen (1:1:1 molar ratio) in H2O, sealed, heated at 170°C for 3 d; cooled, crystd., septd., washed (H2O);	70%

lead(II) perchlorate trihydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → Pb(2-propyl-4,5-imidazole dicarboxylate(-1H))2

Conditions	Yield
In water High Pressure; mixt. of Pb(ClO4)2*3H2O, acid and water stirred 1 h, sealed in Teflon reactor, heated at 160°C for 5 d; cooled to room temp. at 3°C/h; elem. anal.;	69.8%

1,10-Phenanthroline (66-71-7) + cobalt(II) chloride hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → 2C8H9N2O4(1-)*Co(2+)*H2O*C12H8N2

Conditions	Yield
With hydrogenchloride In acetonitrile at 110℃; for 99h; pH=4; Autoclave; High pressure;	69%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) → [Co(2-propylimidazole-4,5-dicarboxylic acid(-H))2(H2O)2]*3H2O

Conditions	Yield
With sodium hydroxide at 80℃; for 2h; pH=3.6;	68%
In water High Pressure; stoich. mixt. in H2O, sealed, heated at 130°C for 144 h; cooled to room temp. in 20 h, crystd., septd., washed (H2O), dried in air, elem. anal.;	56%

cobalt(II) nitrate hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → diaquabis(2-propyl-1H-imidazole-4,5-dicarboxylate)cobalt(II) (1263036-89-0, 1263416-17-6)

Conditions	Yield
In water; acetonitrile High Pressure; mixt. of Co(NO3)2*6H2O and imidazole dicarboxylic acid (1:1) in H2O/CH3CN heated in an autoclave at 152°C for 72 h; cooled to room temp. (10°C/h), collected, washed (h2O), dried (air), elem. anal.;	68%

1,1'-(1,4-butanediyl)bis(imidazole) (69506-86-1) + cadmium(II) perchlorate hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → [Cd2(2-propyl-4,5-imidazoledicarboxylic acid(-1H))2(1,1'-(1,4-butanediyl)bis(imidazole))0.5(H2O)2]

Conditions	Yield
In water High Pressure; Zn compd., ligand, and bbi (2:2:1 molar ratio) in H2O, sealed, heated at140°C for 3 h; cooled (5°C), elem. anal.;	67%

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) + 1,2-diaminopropan (78-90-0, 10424-38-1) → 4C3H10N2*4Co(3+)*9H2O*4C8H7N2O4(3-)

Conditions	Yield
at 120℃; for 24h; Autoclave;	67%

cadmium(II) perchlorate + 1,3-di(4-pyridyl)propane (17252-51-6) + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → 2Cd(2+)*2(C3H7)C3HN2(COO)2(2-)*C5H4N(CH2)3C5H4N*H2O=[Cd2((C3H7)C3HN2(COO)2)2(C5H4N(CH2)3C5H4N)(H2O)]

Conditions	Yield
In water High Pressure; Cd compd.:H2pimdc:bpp (1:1:5 molar ratio) in water, sealed, heated at 140°C for 3 d; crystd. on cooling to room temp., elem. anal.;	66%

1,10-Phenanthroline (66-71-7) + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + copper(II) ion → [Cu(3-propyl-4,5-dicarboxy-1H-imidazole(1-))2(1,10-phenanthroline)]

Conditions	Yield
In water High Pressure; hydrothermal synthesis; 3-propyl-4,5-dicarboxy-1H-imidazole, 1,10-phenanthroline, Cu salt, H2O stirred for 10 min; heated in a sealed Teflon-lined stainless steel autoclave at 170°C for 72 h; cooled to room temp. with 5°C/h; washed with H2O; dried in air; elem. anal.;	66%

manganese (II) sulfate monohydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → diaquabis(2-propyl-1H-imidazole-4,5-dicarboxylate)manganese(II) (1256502-07-4, 1374450-98-2)

Conditions	Yield
In water; acetonitrile High Pressure; mixt. of MnSO4*H2O and imidazole dicarboxylic acid (1:1) in H2O/CH3CN heated in an autoclave at 152°C for 72 h; cooled to room temp. (10°C/h), collected, washed (h2O), dried (air), elem. anal.;	65%

cobalt(II) chloride hexahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + 1,4-phenylenediacetic acid (7325-46-4) → 3Co(2+)*6C8H7N2O4(3-)*C10H10O4*6H2O*12H(1+)

Conditions	Yield
In ethanol; water at 130℃; for 78h; pH=6; Autoclave;	65%

1,10-Phenanthroline (66-71-7) + iron(II) chloride tetrahydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) + water (7732-18-5) → 2C8H9N2O4(1-)*Fe(2+)*H2O*C12H8N2

Conditions	Yield
With hydrogenchloride In acetonitrile at 100℃; for 99h; pH=2; Autoclave; High pressure;	65%

[2,2]bipyridinyl (366-18-7) + manganese (II) sulfate monohydrate + 2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → [Mn(2-propyl-4,5-imidazoledicarboxylate(1-))2(2,2'-bipyridine)]

Conditions	Yield
With sodium hydroxide In ethanol; water; acetonitrile at 130℃; for 48h; pH=6; Sealed tube; High pressure;	63%

Upstream product

• 51802-42-7 2-propylimidazole-4,5-dicarbonitrile 
• 123-72-8 butyraldehyde 
• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 
• 5465-29-2 2-propyl-1H-benzimidazole 
• 87-69-4 L-Tartaric acid 
• 43083-12-1 1,1,1-trimethoxybutane 
• 1187-42-4 diaminomaleonitrile 
• 610-20-8 di-O-nitro-tartaric acid 

Downstream Products

• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 
• 172875-52-4 2-propylimidazole-4-carboxylic acid 
• 752179-89-8 1-((2'-(2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid 
• 144689-63-4 olmesartan 
• 124750-59-0 2-propyl-4,5-bis(methoxycarbonyl)-imidazole 
• 1020157-01-0 (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate 
• 1027174-22-6 5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 
• 172876-04-9 5-Hydroxymethyl-2-propyl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazole-4-carboxylic acid ethyl ester 
• 172875-70-6 5-Isopropenyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 172875-59-1 ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate 
• 172876-01-6 5-Hydroxymethyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 172875-61-5 5-Isopropyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 144689-63-4 olmesartan medoxomil 
• 1026321-00-5 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Preparation method of diacid

The invention relates to a preparation method of diacid, and belongs to the field of medicinal chemistry. The preparation method provided by the invention comprises: carrying out carboxylation reaction on raw materials under the action of acid under a continuous flow reaction condition. The method provided by the invention has the advantages of cheap and easily available raw materials, simple process, low cost, high product purity and yield, green and environment-friendly process, and facilitation of industrialization.

Method for synthesizing 2 -propyl imidazole -4 and 5 - dicarboxylic acid (by machine translation)

The invention provides 2 -propyl imidazole -4 and 5 - dicarboxylic acid synthesis method which uses sodium tungstate and oxidant hydrogen peroxide to synthesize 2 -propylimidazole 2 - and -4 dicarboxylic acid, and the HPLC content of the product is 5 - and the HPLC content of 2 -propylimidazole -4 and 5 - dicarboxylic acid is lower than 99.2percent, namely -4-propyl imidazole 5 - and 0.5percent dicarboxylic acid in a yield of 2 - The present invention provides a method for synthesizing the dicarboxylic acid by co-oxidizing -4-propyl 5 - imidazole with oxidant hydrogen peroxide in PH 85.5percent (by machine translation)

Influence of Oxidation Conditions on the Yield of 2-Substituted Imidazole-4,5-dicarboxylic Acids

Conditions were found which allow 2-alkyl-substituted imidazole-4,5-dicarboxylic acids to be synthesized in preparative quantities by the oxidation of 2-alkylbenzimidazoles with hydrogen peroxide. It was shown that optimal results can be obtained at the concentration of 2-alkylimidazole in sulfuric acid of 1 M and the hydrogen peroxide: 2-alkylbenzimidazole molar ratio of 11: 1. Oxidation under these conditions results in higher yields of the target 2-alkylimidazole-4,5-dicarboxylic acids, including those with a branched alkyl group.

A class of 4, 5 - disubstituted imidazole derivatives and its preparation and use (by machine translation)

The invention relates to a compound of general formula I indicated by the 4, 5 - disubstituted imidazole compound, or its pharmaceutically acceptable salt, pharmaceutical composition containing the same and its preparation and use, the compounds can be used as a xanthine oxidase (Xanthine oxidase, XO) inhibitor, used for the treatment of uric acid crystallization at the joints to the deposition of Gout and its complications. (by machine translation)

Olmesartan high purity intermediate 2-propyl imidazole -4,5-dicarboxylic acid preparation method and application

The invention provides a preparation method of 2-propylimidazolyl-4,5-dicarboxylic acid (1). According to the method, the concentration of the sulfuric acid solution, the volume/mass ratio of the sulfuric acid solution to 2-propyl benzimidazole, the volume ratio of the oxydol to the sulfuric acid water solution, reaction time, added water volume and cooling recrystallization temperature are accurately controlled to obviously lower the content of the impurity imidazolyl-4,5-dicarboxylic acid (8), thereby further obtaining the high-purity olmesartan medoxomil. The invention also provides a compound disclosed as Formula 9 and application thereof in olmesartan medoxomil preparation as a control quality standard substance.

2-aminoalkylimidazole -4, 5-dicarboxilic manufacturing method

PROBLEM TO BE SOLVED: To provide a method for producing inexpensively with a high yield, 2-alkylimidazole-4,5-dicarboxylic acid which is useful as a medicinal intermediate. SOLUTION: In this method for producing 2-alkylimidazole-4,5-dicarboxylic acid, tartaric acid is dissolved into nitric acid and then reacted with concentrated sulfuric acid, and a nitrate of tartaric acid acquired by the reaction is added into a solvent containing at least one kind of organic solvent selected from among N-methyl-2-pyrrolidone, dimethylformamide, dimethylacetamide, methylcyclohexane and toluene. Thereafter, a mixed liquid of aldehyde and ammonia is added to the reaction liquid, to thereby produce 2-alkylimidazole-4,5-dicarboxylic acid. COPYRIGHT: (C)2012,JPOandINPIT

PROCESS FOR (5-METHYL-2-OXO-1,3-DIOXOLEN-4-YL)METHYL4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[4-[2-TETRAZOL-5-YL)PHENYL]PHENYL]METHYLIMIDAZOLE-5-CARBOXYLATE

The present invention relates to an improved process for the preparation of (5-methyl-2-oxo- 1,3-dioxolen-4-yl)methyl4-(1-hydroxy- 1-methylethyl)-2-propyl-1-[4-[2-(tetrazol-5-yl)phenyl]phenyl]methyl imidazole-5-carboxylate.

Efficient synthesis of olmesartan medoxomil, an antihypertensive drug

This document describes a simple and robust process for the synthesis of olmesartan medoxomil. This tailored process allows us to synthesize olmesartan medoxomil on a large scale with 50% overall yield. Also, our process has excellent control of the impurity profile in all the stages. Copyright Taylor & Francis Group, LLC.