2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

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Chemical Name:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one
CAS No.:1361570-04-8
Molecular Formula:C₂₀H₁₁F₅IN₇O
Molecular Weight:587.25
Hs Code.:

Synonyms:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

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Chemical Property of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

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Technology Process of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

There total 17 articles about 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1361569-39-2
6-amino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(2,2,2-trifluoroethyl)-7,9-dihydro-8H-purin-8-one

: 1361570-04-8
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

Guidance literature:: With diiodomethane; isopentyl nitrite; at 85 ℃; for 16h;

Reference yield:

: 1350653-22-3
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)carbamate

: 1361570-04-8
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

2: isopentyl nitrite; diiodomethane / 16 h / 85 °C

With diiodomethane; sodium hexamethyldisilazane; isopentyl nitrite; In tetrahydrofuran;

Reference yield:

: 256504-39-9
ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate

: 1361570-04-8
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic acid / 1,4-dioxane / 72 h / 20 °C / Reflux

2.1: ammonia / methanol

3.1: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C

4.1: sodium methylate / methanol / 2 h / 20 °C

4.2: Reflux

5.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C

5.2: 2 h / 0 °C

5.3: 4 h / 85 - 100 °C

6.1: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide

7.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C

8.2: 48 h / 20 °C

9.1: sodium hexamethyldisilazane / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

10.1: isopentyl nitrite; diiodomethane / 16 h / 85 °C

With pyridine; hydrogenchloride; diiodomethane; palladium 10% on activated carbon; ammonia; hydrogen; sodium methylate; sodium hexamethyldisilazane; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; sodium nitrite; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;