(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

Base Information

Chemical Name:(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate
CAS No.:1439355-11-9
Molecular Formula:C₂₅H₂₂O₆
Molecular Weight:418.446
Hs Code.:

Synonyms:(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

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Chemical Property of (6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

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Technology Process of (6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

There total 9 articles about (6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1439355-08-4
3-(((1R,2R)-1,2-dihydroxy-5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl))methoxyphenyl benzoate

: 1439355-11-9
(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

Guidance literature:: With pyridinium p-toluenesulfonate; In toluene; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3cc42385a

Reference yield:

: 51842-87-6
3-(3,4-dimethoxy-phenyl)-propionyl chloride

: 1439355-11-9
(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium hydride / paraffin oil / 90 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

4: pyridinium p-toluenesulfonate / toluene / Inert atmosphere; Reflux; Dean-Stark

5: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

6: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere

7: AD-mix β; methanesulfonamide; osmium(VIII) oxide / dichloromethane; tert-butyl alcohol; water / 72 h / 20 °C / Inert atmosphere

8: pyridinium p-toluenesulfonate / toluene / 2 h / 90 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; osmium(VIII) oxide; methanesulfonamide; AD-mix β; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; toluene; paraffin oil; tert-butyl alcohol;
DOI:10.1039/c3cc42385a

Reference yield:

: 119035-03-9
5,6-dimethoxy-2-methoxycarbonylindan-1-one

: 1439355-11-9
(6aS,11bR)-6a-hydroxy-9,10-dimethoxy-6,6a,7,11b-tetrahydroindeno[2,1-c]chromen-3-yl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / toluene / Inert atmosphere; Reflux; Dean-Stark

3: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere

5: AD-mix β; methanesulfonamide; osmium(VIII) oxide / dichloromethane; tert-butyl alcohol; water / 72 h / 20 °C / Inert atmosphere

6: pyridinium p-toluenesulfonate / toluene / 2 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; osmium(VIII) oxide; methanesulfonamide; AD-mix β; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1039/c3cc42385a