trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

Base Information

Chemical Name:trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one
CAS No.:1418198-91-0
Molecular Formula:C₁₉H₂₁F₃N₆O₂
Molecular Weight:422.41
Hs Code.:

Synonyms:trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

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Chemical Property of trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

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Technology Process of trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

There total 3 articles about trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418200-33-5
trans-4-(6-benzenesulfonyl-1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

: 1418198-91-0
trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 50 ℃; for 18h;

Reference yield:

: 1418200-32-4
trans-2-oxo-oxazolidine-4-carboxylic acid (1-benzenesulfonyl-4-[4-(2,2,2-trifluoro-ethylamino)-cyclohexylamino]-1H-pyrrolo[2,3-b]pyridin-5-yl)-amide

: 1418198-91-0
trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 18 h / 80 °C

2: sodium hydroxide / water; isopropyl alcohol / 18 h / 50 °C

With acetic acid; sodium hydroxide; In water; isopropyl alcohol;

Reference yield:

: 1418200-53-9
trans-1-benzenesulfonyl-N₄-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

: 1418198-91-0
trans-4-(1-[4-(2,2,2-trifluoro-ethylamino)-cyclohexyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1.5 h / 60 °C

2: acetic acid / 18 h / 80 °C

3: sodium hydroxide / water; isopropyl alcohol / 18 h / 50 °C

With pyridine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In water; isopropyl alcohol;