propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

Base Information

Chemical Name:propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate
CAS No.:1559057-73-6
Molecular Formula:C₂₉H₃₈F₂O₇
Molecular Weight:536.613
Hs Code.:

Synonyms:propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

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Chemical Property of propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

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Technology Process of propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

There total 7 articles about propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

: 1559057-59-8
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3-oxo-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

: 1559057-73-6
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 - 30 ℃; for 72h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: 1559057-77-0,130209-78-8
C₂₅H₃₆O₆

: 1559057-73-6
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane / 11 h / 25 - 40 °C

2: triethylamine; dmap / dichloromethane / 1 h / 25 °C

3: Deoxo-Fluor / tetrahydrofuran; dichloromethane / 26 h / 0 - 40 °C

With dmap; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 40665-68-7
dimethyl (3-phenoxy-2-oxopropyl)phosphonate

: 1559057-73-6
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; tetrabutylammomium bromide / dichloromethane / 1 h / 20 - 30 °C

1.2: 15 h / 20 °C

2.1: toluene-4-sulfonic acid / methanol / 15 h / 0 °C

3.1: triethylamine; dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 72 h / 20 - 30 °C

With dmap; n-butyllithium; tetrabutylammomium bromide; toluene-4-sulfonic acid; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In methanol; dichloromethane; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;