40665-68-7 Usage
Description
DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE, also known as Travopropst (T715600), is a compound that acts as a selective FP prostaglandin receptor agonist. It is the isopropyl ester of (+)-fluprostenol, a prostaglandin analog, and is characterized by its ability to interact with specific receptors in the body, playing a role in various physiological processes.
Uses
Used in Pharmaceutical Industry:
DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE is used as an active pharmaceutical ingredient for its antiglaucoma properties. It helps in the treatment of glaucoma by reducing intraocular pressure, which is a primary risk factor for vision loss in patients with this condition.
Used in Research and Development:
DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE is used as a key compound in the synthesis of novel prostanoid thromboxane A2 agonists. These agonists have potential applications in various medical fields, including the treatment of cardiovascular and respiratory diseases, as well as other conditions that involve the prostanoid system.
Check Digit Verification of cas no
The CAS Registry Mumber 40665-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,6 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 40665-68:
(7*4)+(6*0)+(5*6)+(4*6)+(3*5)+(2*6)+(1*8)=117
117 % 10 = 7
So 40665-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15O5P/c1-14-17(13,15-2)9-10(12)8-16-11-6-4-3-5-7-11/h3-7H,8-9H2,1-2H3
40665-68-7Relevant articles and documents
He fluorine front row element intermediate preparation method (by machine translation)
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Paragraph 0034; 0035; 0036, (2018/05/16)
The invention discloses he fluorine front row element intermediate, i.e. formula 5 compound preparation method, including the use of biphenyl formyl protected Corey lactone as raw materials, through oxidation, HWE connected side chain, fluorinated, hydrolysis of deprotection step. Preparation method of this invention has the operability is strong, stable process, intermediates for the preparation of white powder, good stability. (by machine translation)
Synthesis of (±) travoprost and its analogs
Mudduluru, Harikrishna,Hindupur, Rama M.,Dubey, Pramod K.,Madhavaram, Shankar,Tatini, Lakshmikumar,Subbaraju, Gottumukkala V.
experimental part, p. 234 - 241 (2012/04/18)
A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives
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, (2008/06/13)
Disclosed herein are novel prostaglandin I2 (PGI2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: STR1 wherein R1, X, R2 and R3 are as defined herein.