C₂₁H₁₂F₇NO

Base Information

Chemical Name:C₂₁H₁₂F₇NO
CAS No.:1357018-82-6
Molecular Formula:C₂₁H₁₂F₇NO
Molecular Weight:427.321
Hs Code.:

C<sub>21</sub>H<sub>12</sub>F<sub>7</sub>NO

Synonyms:C₂₁H₁₂F₇NO

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Chemical Property of C₂₁H₁₂F₇NO

Chemical Property:

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Technology Process of C₂₁H₁₂F₇NO

There total 4 articles about C₂₁H₁₂F₇NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1357018-82-6
C₂₁H₁₂F₇NO

Guidance literature:: With sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; at 20 - 75 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1357018-82-6
C₂₁H₁₂F₇NO

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 4.5 h / 20 - 75 °C / Inert atmosphere

With n-butyllithium; copper; sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; diethyl ether; dimethyl sulfoxide;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1357018-82-6
C₂₁H₁₂F₇NO

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

2: diethyl ether / 2 h / 0 - 20 °C

3: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 4.5 h / 20 - 75 °C / Inert atmosphere

With n-butyllithium; sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; diethyl ether;