C₃₂H₄₃BN₂O₅

Base Information

• Chemical Name: C₃₂H₄₃BN₂O₅
• CAS No.: 1422969-07-0
• Molecular Formula: C₃₂H₄₃BN₂O₅
• Molecular Weight: 546.515
• Mol file: 1422969-07-0.mol

Synonyms:C₃₂H₄₃BN₂O₅

Chemical Property of C₃₂H₄₃BN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₃BN₂O₅

There total 1 articles about C₃₂H₄₃BN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-L-Phe (1161-13-3) + C15H28BNO2*ClH (945606-99-5,779357-85-6) → C32H43BN2O5 (1422969-07-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmc.2012.11.045

Reference yield:

C32H43BN2O5 (1422969-07-0) → C21H27BN2O4 (1422969-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: methanol / Acidic conditions

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.11.045

Reference yield:

C32H43BN2O5 (1422969-07-0) → [(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid (1132709-14-8,1132709-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: methanol / Acidic conditions

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.11.045

upstream raw materials:

N-Cbz-L-Phe

C₁₅H₂₈BNO₂*ClH

Downstream raw materials:

C₂₁H₂₇BN₂O₄

[(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid

C₃₁H₄₁BN₂O₄