5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

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Chemical Name:5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one
CAS No.:1204122-71-3
Molecular Formula:C₄₈H₆₆N₆O₄Si
Molecular Weight:819.175
Hs Code.:

5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

Synonyms:5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

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Chemical Property of 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

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Technology Process of 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

There total 10 articles about 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1204122-69-9
8-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]quinolin-2(1H)-one

: 1204122-71-3
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:: With ammonium formate; palladium diacetate; In ethanol; at 78 ℃; for 2h;
DOI:10.1016/j.bmcl.2015.10.008

Reference yield: 91.0%

: 1204122-71-3
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:

Reference yield:

: 1204122-42-8
tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate

: 1204122-71-3
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / butanone / 24 h / 90 °C

3: hydrazine hydrate / ethanol / 1 h / 20 °C

4: sodium hydrogencarbonate / acetonitrile / 72 h / 90 °C

5: palladium diacetate; ammonium formate / ethanol / 2 h / 78 °C

With hydrogenchloride; ammonium formate; palladium diacetate; sodium hydrogencarbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; acetonitrile; butanone;
DOI:10.1016/j.bmcl.2015.10.008