2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

Base Information

• Chemical Name: 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate
• CAS No.: 1439358-81-2
• Molecular Formula: C₂₆H₂₄N₂O₆
• Molecular Weight: 460.486

Synonyms:2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

Chemical Property of 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

Chemical Property:

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Technology Process of 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate

There total 2 articles about 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-cyanoethyl 4a-bromo-2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4a,5-dihydroindeno[1,2-b]pyridine-3-carboxylate (1439358-84-5) → 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate (1439358-81-2)

Guidance literature:

2-cyanoethyl 4a-bromo-2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4a,5-dihydroindeno[1,2-b]pyridine-3-carboxylate; With sodium hydroxide; In water; acetone; at 20 ℃; for 0.0333333h;

With hydrogenchloride; In water; acetone; pH=4 - 5;

DOI:10.1016/j.tet.2013.04.060

Reference yield: 70.0%

2-(3,4,5 trimethoxybenzylidene)-1H-indene-1,3(2H)-dione (24760-34-7) + 2-cyanoethylacetoacetate (65193-87-5) → 2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate (1439358-81-2)

Guidance literature:

With ammonium acetate; acetic acid; for 0.5h; Reflux;

DOI:10.1016/j.tet.2013.04.060

Reference yield: 79.0%

2-cyanoethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate (1439358-81-2) → 2-cyanoethyl 4a-bromo-2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4a,5-dihydroindeno[1,2-b]pyridine-3-carboxylate (1439358-84-5)

Guidance literature:

With N-Bromosuccinimide; In methanol; at 10 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2013.04.060

upstream raw materials:

2-(3,4,5 trimethoxybenzylidene)-1H-indene-1,3(2H)-dione

2-cyanoethylacetoacetate

2-cyanoethyl 4a-bromo-2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4a,5-dihydroindeno[1,2-b]pyridine-3-carboxylate

Downstream raw materials:

2-cyanoethyl 4a-bromo-2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-4a,5-dihydroindeno[1,2-b]pyridine-3-carboxylate

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