cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Base Information

Chemical Name:cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide
CAS No.:1022973-49-4
Molecular Formula:C₂₆H₃₇ClN₆O₃S
Molecular Weight:549.137
Hs Code.:

cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Synonyms:cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Suppliers and Price of cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

There total 4 articles about cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022973-44-9
N⁽⁴⁾-((1R,2R)-2-aminocyclohexyl)-5-chloro-N⁽²⁾-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]pyrimidine-2,4-diamine

: 139631-62-2
cyclopropanesulfonyl chloride

: 1022973-49-4
cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1245830-90-3
(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine

: 1022973-49-4
cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2: hydrogenchloride / 1,4-dioxane; ethyl methyl ether / 120 °C

3: water; potassium hydroxide / methanol / 7 h / 60 °C

4: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl methyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1022973-35-8
N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

: 1022973-49-4
cyclopropanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; ethyl methyl ether / 120 °C

2: water; potassium hydroxide / methanol / 7 h / 60 °C

3: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; ethyl methyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2011.05.040