ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

Base Information

Chemical Name:ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate
CAS No.:1202576-69-9
Molecular Formula:C₂₅H₂₆F₃NO₄S
Molecular Weight:493.547
Hs Code.:

Synonyms:ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

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Chemical Property of ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

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Technology Process of ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

There total 4 articles about ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1202576-67-7
ethyl 3-ethoxy-3-(4-hydroxyphenyl)propionate

: 317318-96-0
[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol

: 1202576-69-9
ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 50 ℃; Inert atmosphere;

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 1202576-69-9
ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; toluene;

Reference yield:

: 1202576-66-6
ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-ethoxypropionate

: 1202576-69-9
ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;