7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine

Base Information

• Chemical Name: 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine
• CAS No.: 869284-26-4
• Molecular Formula: C₁₈H₁₃F₃O₄
• Molecular Weight: 350.294
• Mol file: 869284-26-4.mol

Synonyms:7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine

Chemical Property of 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine

There total 4 articles about 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-iodo-7-methoxy-3-(4-methoxyphenyl)isocoumarine (869284-19-5) + 2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) → 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine (869284-26-4)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

DOI:10.1016/j.bmc.2005.07.014

Reference yield:

5-methoxy-2-trifluoromethanesulfonyloxy benzoic acid methyl ester (345924-12-1) → 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine (869284-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / triethylamine; CuI; tetrabutylammonium iodide / Pd(PPh₃)4 / acetonitrile / 4 h / Heating

2: 73 percent / I₂ / acetonitrile / 2 h / 20 °C

3: 81 percent / CuI / dimethylformamide / 6 h / 80 °C

With copper(l) iodide; iodine; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; acetonitrile; 1: Sonogashira coupling;

DOI:10.1016/j.bmc.2005.07.014

Reference yield:

methyl 5-methoxy-2-hydroxybenzoate (2905-82-0) → 7-methoxy-3-(4-methoxyphenyl)-4-trifluoromethylisocoumarine (869284-26-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / triethylamine / toluene / 1 h / 20 °C

2: 75 percent / triethylamine; CuI; tetrabutylammonium iodide / Pd(PPh₃)4 / acetonitrile / 4 h / Heating

3: 73 percent / I₂ / acetonitrile / 2 h / 20 °C

4: 81 percent / CuI / dimethylformamide / 6 h / 80 °C

With copper(l) iodide; iodine; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; acetonitrile; 2: Sonogashira coupling;

DOI:10.1016/j.bmc.2005.07.014

upstream raw materials:

4-iodo-7-methoxy-3-(4-methoxyphenyl)isocoumarine

2,2-difluoro-2-(fluorosulfonyl)acetate

5-methoxy-2-trifluoromethanesulfonyloxy benzoic acid methyl ester

5-methoxy-2-(4-methoxyphenylethynyl)benzoic acid methyl ester