2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione
CAS No.:121963-28-8
Molecular Formula:C₃₃H₃₂F₃N₃O₅
Molecular Weight:607.629
Hs Code.:

Synonyms:2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

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Chemical Property of 2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

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Technology Process of 2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

There total 9 articles about 2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 63460-47-9
2-(4-iodopentyl)-1,3-isoindolinedione

: 121963-27-7
2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

: 121963-28-8
2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

Guidance literature:: With diisopropylamine; In acetonitrile; Heating;
DOI:10.1021/jm00128a010

Reference yield:

: 81358-81-8
4-methyl-5-hydroxy-6-methoxy-8-nitroquinoline

: 121963-28-8
2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 45 percent / tetrabutylammonium hydroxide / chlorobenzene; H₂O / 120 h / 60 - 65 °C

2: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

3: 89 percent / xylene / Heating

4: 83 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

5: 83 percent / POCl₃ / CHCl₃ / Heating

6: 89 percent / N₂H₄*H₂O / ethanol; H₂O / Heating

7: 45 percent / NaH / dimethylformamide; paraffin

8: 35 percent / diisopropylamine / acetonitrile / Heating

With tetra(n-butyl)ammonium hydroxide; hydrogen; sodium hydride; hydrazine hydrate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; chlorobenzene; acetonitrile; paraffin; xylene;
DOI:10.1021/jm00128a010

Reference yield:

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

: 121963-28-8
2-{4-[2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

2: 89 percent / xylene / Heating

3: 83 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

4: 83 percent / POCl₃ / CHCl₃ / Heating

5: 89 percent / N₂H₄*H₂O / ethanol; H₂O / Heating

6: 45 percent / NaH / dimethylformamide; paraffin

7: 35 percent / diisopropylamine / acetonitrile / Heating

With hydrogen; sodium hydride; hydrazine hydrate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile; paraffin; xylene;
DOI:10.1021/jm00128a010