2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Base Information

Chemical Name:2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine
CAS No.:121963-27-7
Molecular Formula:C₂₀H₁₉F₃N₂O₃
Molecular Weight:392.378
Hs Code.:

Synonyms:2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

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Chemical Property of 2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Chemical Property:

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Technology Process of 2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

There total 8 articles about 2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 67-56-1
methanol

: 121963-26-6
2-Chloro-6-methoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

: 121963-27-7
2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00128a010

Reference yield:

: 81358-81-8
4-methyl-5-hydroxy-6-methoxy-8-nitroquinoline

: 121963-27-7
2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 45 percent / tetrabutylammonium hydroxide / chlorobenzene; H₂O / 120 h / 60 - 65 °C

2: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

3: 89 percent / xylene / Heating

4: 83 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

5: 83 percent / POCl₃ / CHCl₃ / Heating

6: 89 percent / N₂H₄*H₂O / ethanol; H₂O / Heating

7: 45 percent / NaH / dimethylformamide; paraffin

With tetra(n-butyl)ammonium hydroxide; hydrogen; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; chlorobenzene; paraffin; xylene;
DOI:10.1021/jm00128a010

Reference yield:

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

: 121963-27-7
2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

2: 89 percent / xylene / Heating

3: 83 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

4: 83 percent / POCl₃ / CHCl₃ / Heating

5: 89 percent / N₂H₄*H₂O / ethanol; H₂O / Heating

6: 45 percent / NaH / dimethylformamide; paraffin

With hydrogen; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; paraffin; xylene;
DOI:10.1021/jm00128a010