3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

Base Information

Chemical Name:3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride
CAS No.:173737-61-6
Molecular Formula:C₁₆H₂₇ClO₃Si
Molecular Weight:330.927
Hs Code.:

Synonyms:3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

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Chemical Property of 3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

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Technology Process of 3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

There total 6 articles about 3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 173737-60-5
3,4-dimethoxy-N,N-dimethyl-2-(((1,1-dimethylethyl)dimethylsilyl)oxy)methylbenzylamine

: 173737-61-6
3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

Guidance literature:: With chloroformic acid ethyl ester; potassium carbonate; In tetrahydrofuran; for 13h; Ambient temperature;
DOI:10.1021/jo951611q

Reference yield:

: 65495-21-8
N,N-dimethyl-3,4-dimethoxybenzylamine

: 173737-61-6
3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 4 h, 2.) room temperature, 4 h

2: i-Pr₂NH / CH₂Cl₂ / 1 h

3: 87 percent / K₂CO₃, ClCO₂Et / tetrahydrofuran / 13 h / Ambient temperature

With n-butyllithium; chloroformic acid ethyl ester; potassium carbonate; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo951611q

Reference yield:

: 6967-45-9
3,4-dimethoxy-N,N-dimethylbenzamide

: 173737-61-6
3,4-dimethoxy-2-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)benzyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 4 h, 2.) room temperature, 4 h

3: i-Pr₂NH / CH₂Cl₂ / 1 h

4: 87 percent / K₂CO₃, ClCO₂Et / tetrahydrofuran / 13 h / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; chloroformic acid ethyl ester; potassium carbonate; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo951611q