4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide

Base Information

• Chemical Name: 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide
• CAS No.: 1346263-98-6
• Molecular Formula: C₃₇H₅₄N₈O₃
• Molecular Weight: 658.888

Synonyms:4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide

Chemical Property of 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide

There total 6 articles about 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

1,8-diazidooctane (98560-17-9) + N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxy-4-(pent-4-yn-1-yloxy)benzamide (1346263-96-4) → 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide (1346263-98-6)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In methanol; dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm2009919

Reference yield:

1-chloro-4-pentyne (14267-92-6) → 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide (1346263-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 20 h / Reflux

2: potassium hydroxide / methanol / 1.5 h / 60 °C

3: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 2 h / 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm2009919

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide (1346263-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 20 h / Reflux

2: potassium hydroxide / methanol / 1.5 h / 60 °C

3: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 2 h / 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm2009919

upstream raw materials:

N¹-(2,3-dihydro-1H-inden-2-yl)-N¹-(prop-1-yl)butane-1,4-diamine

methyl 3-methoxy-4-(pent-4-yn-1-yloxy)benzoate

3-methoxy-4-(pent-4-yn-1-yloxy)benzoic acid

1,8-diazidooctane

Downstream raw materials:

4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1346263-98-6 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send