4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Base Information

• Chemical Name: 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide
• CAS No.: 1346263-91-9
• Molecular Formula: C₆₅H₉₁N₁₁O₇
• Molecular Weight: 1138.51

Synonyms:4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Chemical Property of 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

Chemical Property:

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Safty Information:

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Useful:

Technology Process of 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide

There total 8 articles about 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-4-(pent-4-yn-1-yloxy)benzamide (1346263-97-5) + 4-[3-[1-(8-azidooctyl)-1H-1,2,3-triazol-4-yl]propoxy]-N-[4-[(indan-2-yl)(propyl)amino]butyl]-3-methoxybenzamide (1346263-98-6) → 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-91-9)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In methanol; dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm2009919

Reference yield:

methyl 3-methoxy-4-(pent-4-yn-1-yloxy)benzoate (1346263-87-3) → 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / methanol / 1.5 h / 60 °C

2: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 2 h / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 16 h / 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009919

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 4-[3-[1-[8-[4-[3-[4-[[[4-[(indan-2-yl)(propyl)amino]butyl]amino]carbonyl]-2-methoxyphenoxy]propyl]-1H-1,2,3-triazol-1-yl]octyl]-1H-1,2,3-triazol-4-yl]propoxy]-3-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide (1346263-91-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / acetonitrile / 20 h / Reflux

2: potassium hydroxide / methanol / 1.5 h / 60 °C

3: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 2 h / 20 °C

5: copper(ll) sulfate pentahydrate; sodium L-ascorbate / methanol; dichloromethane / 16 h / 20 °C

With copper(ll) sulfate pentahydrate; 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm2009919

upstream raw materials:

N¹-(2,3-dihydro-1H-inden-2-yl)-N¹-(prop-1-yl)butane-1,4-diamine

methyl 3-methoxy-4-(pent-4-yn-1-yloxy)benzoate

3-methoxy-4-(pent-4-yn-1-yloxy)benzoic acid

4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

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