N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

Base Information

Chemical Name:N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide
CAS No.:1360430-65-4
Molecular Formula:C₂₆H₂₇ClFN₅O₂
Molecular Weight:495.984
Hs Code.:

Synonyms:N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

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Chemical Property of N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

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Technology Process of N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

There total 8 articles about N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 110-89-4
piperidine

: 1360430-72-3
3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

: 1360430-65-4
N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

Guidance literature:: piperidine; 3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide; With potassium iodide; In ethanol; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃;
DOI:10.1021/jm201507x

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1360430-65-4
N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine hydrochloride / isopropyl alcohol / Reflux

2.1: hydrogenchloride / water / Reflux

3.1: 50 °C

4.1: potassium iodide / ethanol / Reflux

4.2: 0 °C

With hydrogenchloride; pyridine hydrochloride; potassium iodide; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 1201080-09-2,848133-75-5
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

: 1360430-65-4
N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-piperidin-1-ylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C

2.1: pyridine hydrochloride / isopropyl alcohol / Reflux

3.1: hydrogenchloride / water / Reflux

4.1: 50 °C

5.1: potassium iodide / ethanol / Reflux

5.2: 0 °C

With hydrogenchloride; pyridine hydrochloride; potassium iodide; trichlorophosphate; In ethanol; diethylene glycol dimethyl ether; water; isopropyl alcohol;
DOI:10.1021/jm201507x