3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

Base Information

Chemical Name:3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide
CAS No.:1360430-72-3
Molecular Formula:C₂₁H₁₇Cl₂FN₄O₂
Molecular Weight:447.296
Hs Code.:

Synonyms:3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

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Technology Process of 3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

There total 7 articles about 3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 625-36-5
2-chloropropionyl chloride

: 361162-95-0
6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile

: 1360430-72-3
3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

Guidance literature:: at 50 ℃;
DOI:10.1021/jm201507x

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1360430-72-3
3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine hydrochloride / isopropyl alcohol / Reflux

2: hydrogenchloride / water / Reflux

3: 50 °C

With hydrogenchloride; pyridine hydrochloride; In water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 1201080-09-2,848133-75-5
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

: 1360430-72-3
3-chloro-N-(4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C

2: pyridine hydrochloride / isopropyl alcohol / Reflux

3: hydrogenchloride / water / Reflux

4: 50 °C

With hydrogenchloride; pyridine hydrochloride; trichlorophosphate; In diethylene glycol dimethyl ether; water; isopropyl alcohol;
DOI:10.1021/jm201507x