(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Base Information

Chemical Name:(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid
CAS No.:324012-42-2
Molecular Formula:C₂₄H₂₆N₂O₃S
Molecular Weight:422.548
Hs Code.:

Synonyms:(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Suppliers and Price of (3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

There total 8 articles about (3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 324012-40-0
(3aS,6aR)-1,3-Dibenzyl-4-(5-oxohexylidene)tetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one

: 324012-42-2
(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Guidance literature:: With sodium hydroxide; iodine; potassium iodide; In 1,4-dioxane; at 60 ℃; for 2h;
DOI:10.1055/s-2000-8716

Reference yield:

: 28092-52-6
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

: 324012-42-2
(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; I₂ / tetrahydrofuran / 1.5 h / Heating

1.2: tetrahydrofuran / Heating

2.1: 13.8 g / aq. H₂SO₄ / tetrahydrofuran / 2 h / 60 °C

3.1: 75 percent / I₂; KI; aq. NaOH / dioxane / 2 h / 60 °C

With sodium hydroxide; sulfuric acid; iodine; magnesium; potassium iodide; In tetrahydrofuran; 1,4-dioxane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Dehydration / 3.1: Oxidation;
DOI:10.1055/s-2000-8716

Reference yield:

: 324012-37-5
cis-1,3-Dibenzyltetrahydro-2H-thieno[3,4-d]imidazole-2,4,6-trione

: 324012-42-2
(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / (R)-BINAL-H / tetrahydrofuran / 6 h / -78 °C

2.1: Mg; I₂ / tetrahydrofuran / 1.5 h / Heating

2.2: tetrahydrofuran / Heating

3.1: 13.8 g / aq. H₂SO₄ / tetrahydrofuran / 2 h / 60 °C

4.1: 75 percent / I₂; KI; aq. NaOH / dioxane / 2 h / 60 °C

With sodium hydroxide; (R)-BINAL-H; sulfuric acid; iodine; magnesium; potassium iodide; In tetrahydrofuran; 1,4-dioxane; 1.1: Reduction / 2.1: Metallation / 2.2: Grignard reaction / 3.1: Dehydration / 4.1: Oxidation;
DOI:10.1055/s-2000-8716