324012-40-0Relevant articles and documents
An efficient and enantioselective synthesis of d-biotin
Chen,Huang,Fu,Cheng,Zhang,Li,Peng
, p. 2004 - 2008 (2007/10/03)
An efficient and enantioselective synthesis of d-biotin 1 starting from cis-1,3-dibenzyl-2-imidazo-lidone-4,5-dicarboxylic acid (6) is described. The key steps are the enantioselective reduction of meso-1,2-dicarboxylic thioanhydride 8 to prepare the (3as, 6ar)- thiolactone 9 and the introduction of the C6 side chain at C-2 in 9 via a modified Grignard reaction. This novel synthesis proceeded in six steps to afford 1 with 21% overall yield.