5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

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Chemical Name:5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one
CAS No.:882175-70-4
Molecular Formula:C₃₀H₄₅NO₄Si
Molecular Weight:511.777
Hs Code.:

5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

Synonyms:5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

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Chemical Property of 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

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Technology Process of 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

There total 16 articles about 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 882175-69-1
5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1-(4-methoxy-benzyloxy)-1H-pyridin-2-one

: 882175-70-4
5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

Guidance literature:: With copper bis(oxazoline); tert-butylperoxy-4-nitrobenzoate; In acetone; at 22 ℃;
DOI:10.3987/com-05-s(t)70

Reference yield:

: 3413-44-3
(R)-2-cyclohexen-1-ol

: 882175-70-4
5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: 84 percent / imidazole / CH₂Cl₂

2.1: m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 0 °C

3.1: [C(CH₃)2(CH₂)3C(CH₃)2]NLi / hexane; benzene / 0 - 20 °C

4.1: 87 percent / tri-n-butylphosphine / CH₂Cl₂ / 0.08 h / 22 °C

5.1: 86 percent / DIBAL / toluene

6.1: 97 percent / imidazole / CH₂Cl₂

7.1: toluene / 180 °C

8.1: PPTs; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

8.2: NaCNBH₃ / acetic acid / 10 °C

9.1: 56 percent / benzotriazol-1-yloxytris(Me₂N)phosphonium hexaFphosphate

10.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

10.2: NaClO₂; NaH₂PO₄ / acetonitrile; H₂O; 2-methyl-propan-2-ol / 0 °C

10.3: 58 percent / 1,1'carbonyldiimidazole; NaH / dimethylformamide / 20 °C

11.1: 76 percent / BrCCl₃; (Me₂N)2C=NH / CH₂Cl₂ / 22 °C

12.1: 44 percent / tert-butylperoxy-4-nitrobenzoate; copper bis(oxazoline) complex / acetone / 22 °C

With 1H-imidazole; Bromotrichloromethane; tributylphosphine; 4 A molecular sieve; copper bis(oxazoline); tert-butylperoxy-4-nitrobenzoate; 2,2,6,6-tetramethylpiperidinyl-lithium; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; N,N,N',N'-tetramethylguanidine; In hexane; dichloromethane; acetone; toluene; benzene; 12.1: Karash oxidation;
DOI:10.3987/com-05-s(t)70

Reference yield:

: 872472-36-1
3-((1S,2S,4aR,6S,8aS)-2,6-Dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-3-oxo-propionic acid

: 882175-70-4
5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 56 percent / benzotriazol-1-yloxytris(Me₂N)phosphonium hexaFphosphate

2.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

2.2: NaClO₂; NaH₂PO₄ / acetonitrile; H₂O; 2-methyl-propan-2-ol / 0 °C

2.3: 58 percent / 1,1'carbonyldiimidazole; NaH / dimethylformamide / 20 °C

3.1: 76 percent / BrCCl₃; (Me₂N)2C=NH / CH₂Cl₂ / 22 °C

4.1: 44 percent / tert-butylperoxy-4-nitrobenzoate; copper bis(oxazoline) complex / acetone / 22 °C

With Bromotrichloromethane; copper bis(oxazoline); tert-butylperoxy-4-nitrobenzoate; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; N,N,N',N'-tetramethylguanidine; In dichloromethane; acetone; 4.1: Karash oxidation;
DOI:10.3987/com-05-s(t)70