N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide
CAS No.:479546-83-3
Molecular Formula:C₂₁H₂₂N₄O₄
Molecular Weight:394.43
Hs Code.:

<i>N</i>-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-2-yl]-2,2-dimethyl-propionamide

Synonyms:N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

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Chemical Property of N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

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Technology Process of N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

There total 3 articles about N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 22944-08-7
2-ethynyl-1,4-dimethoxybenzene

: 143682-15-9
6-iodo-4(3H)-oxo-2-pivaloylamino-7H-pyrrolo<2,3-d>pyrimidine

: 479546-83-3
N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1002/jhet.5570390433

Reference yield:

: 1201-38-3
2',5'-dimethoxyacetophenone

: 479546-83-3
N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / PCl₅ / benzene / 5 h / Heating

2: 81 percent / KOH / ethanol / 48 h / Heating

3: 36 percent / CuI; Et₃N / tetrakis(triphenylphosphane)palladium⁽⁰⁾ / dimethylformamide / 72 h / 20 °C

With potassium hydroxide; copper(l) iodide; phosphorus pentachloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; benzene; 3: Sonogashira coupling reaction;
DOI:10.1002/jhet.5570390433

Reference yield:

: 104970-98-1
1-chloro-1-(2,5-dimethoxyphenyl)ethene

: 479546-83-3
N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / KOH / ethanol / 48 h / Heating

2: 36 percent / CuI; Et₃N / tetrakis(triphenylphosphane)palladium⁽⁰⁾ / dimethylformamide / 72 h / 20 °C

With potassium hydroxide; copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; 2: Sonogashira coupling reaction;
DOI:10.1002/jhet.5570390433