6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Base Information

Chemical Name:6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
CAS No.:1235842-23-5
Molecular Formula:C₁₉H₁₈F₃N₅O
Molecular Weight:389.38
Hs Code.:

Synonyms:6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

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Chemical Property of 6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

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Technology Process of 6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

There total 2 articles about 6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104382-43-5
2-[4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl methanesulfonate

: 75-04-7,85404-22-4
ethylamine

: 1235842-23-5
6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: 2-[4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl methanesulfonate; ethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.333333h; Microwave conditions;

With trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; Acidic prep HPLC;

With ammonia; In methanol;

Reference yield:

: 6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

: 1235842-23-5
6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: 6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile trifluoroacetate; In methanol;

With ammonia; In methanol;

Reference yield:

: 1235842-23-5
6-(4-(2-(ethylamino)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

: 475-11-6,58123-62-9,68078-09-1
N-methyl-L-proline

: 1235841-59-4
(S)-N-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)-phenoxy)ethyl)-N-ethyl-1-methylpyrrolidine-2-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 60h;