(3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Base Information

• Chemical Name: (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane
• CAS No.: 104946-94-3
• Molecular Formula: C₂₉H₃₂N₂O₄
• Molecular Weight: 472.584

Synonyms:(3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Chemical Property of (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Chemical Property:

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Technology Process of (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

There total 6 articles about (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione (104946-93-2) → (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane (104946-94-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 25 ℃; for 3h; under 760 Torr;

DOI:10.1021/jm00384a026

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane (104946-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / AcOH / 3 h / Heating

2: 83 percent / H₂ / 5percent Pd/C / acetic acid / 3 h / 25 °C / 760 Torr

With hydrogen; acetic acid; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00384a026

Reference yield:

(3R*,4S*)-3-<3-(3-aminopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane (104946-86-3) → (3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane (104946-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / AcOH / 3 h / Heating

2: 83 percent / H₂ / 5percent Pd/C / acetic acid / 3 h / 25 °C / 760 Torr

With hydrogen; acetic acid; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00384a026

upstream raw materials:

2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

3-nitrophthalic acid anhydride

(3R*,4S*)-3-<3-(3-aminopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propan-1-ol

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