3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Base Information

Chemical Name:3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid
CAS No.:157035-19-3
Molecular Formula:C₂₅H₃₆O₆Si
Molecular Weight:460.643
Hs Code.:

Synonyms:3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Suppliers and Price of 3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

There total 11 articles about 3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 157035-18-2
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

: 157035-19-3
3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; Ambient temperature;
DOI:10.1016/S0040-4039(00)73369-7

Reference yield:

: 157035-15-9
O-benzyl-3-(4-bromophenyl)-2-hydroxypropanol

: 157035-19-3
3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

2: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

3: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 2 h / 0 - 25 °C

4: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 25 °C

With 1H-imidazole; lithium hydroxide; copper(I) bromide dimethylsulfide complex; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8

Reference yield:

: 24393-53-1,136265-11-7,15795-20-7
ethyl (E)-3-(4-bromophenyl)-2-propenoate

: 157035-19-3
3-(3-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / DIBAL-H / CH₂Cl₂; hexane / 0.17 h / -78 °C

2: 94 percent / NaH, Bu₄NI / tetrahydrofuran / 1.) 0 to 25 deg C, 30 min, 2.) 25 deg C, 3 h

3: 82 percent / m-CPBA / CH₂Cl₂ / 4 h / 25 °C

4: 86 percent / DIBAL-H / toluene / 0.17 h / 0 °C

5: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

6: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

7: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 2 h / 0 - 25 °C

8: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 25 °C

With 1H-imidazole; lithium hydroxide; copper(I) bromide dimethylsulfide complex; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8