3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

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Chemical Name:3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid
CAS No.:157035-18-2
Molecular Formula:C₃₂H₄₂O₆Si
Molecular Weight:550.767
Hs Code.:

Synonyms:3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

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Chemical Property of 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

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Technology Process of 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

There total 10 articles about 3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 157035-17-1
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid ethyl ester

: 157035-18-2
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; for 2h; 0 deg C -> r.t.;
DOI:10.1016/S0040-4039(00)73369-7

Reference yield:

: 24393-53-1,136265-11-7,15795-20-7
ethyl (E)-3-(4-bromophenyl)-2-propenoate

: 157035-18-2
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / DIBAL-H / CH₂Cl₂; hexane / 0.17 h / -78 °C

2: 94 percent / NaH, Bu₄NI / tetrahydrofuran / 1.) 0 to 25 deg C, 30 min, 2.) 25 deg C, 3 h

3: 82 percent / m-CPBA / CH₂Cl₂ / 4 h / 25 °C

4: 86 percent / DIBAL-H / toluene / 0.17 h / 0 °C

5: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

6: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

7: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 2 h / 0 - 25 °C

With 1H-imidazole; lithium hydroxide; copper(I) bromide dimethylsulfide complex; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8

Reference yield:

: 202645-40-7
O-benzyl-3-(4-bromophenyl)-2,3-epoxypropanol

: 157035-18-2
3-(3-{4-[3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DIBAL-H / toluene / 0.17 h / 0 °C

2: 97 percent / imidazole / dimethylformamide / 3 h / 25 °C

3: 92 percent / K₂CO₃, CuBr*Me₂S / pyridine / 6 h / 140 °C

4: 94 percent / aq. LiOH / tetrahydrofuran; methanol / 2 h / 0 - 25 °C

With 1H-imidazole; lithium hydroxide; copper(I) bromide dimethylsulfide complex; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8